Barzilai University Medical Center

38 Research Day 2020 Barzilai University Medical Center 22 FEVER OF UNKNOWN ORIGIN -DIFFERENT CENTURIES - DIFFERENT PATTERNS Zafrir-Haver Shirley, Demian Halperin Bayer Rose, Haver Guy, Zamir Mariana Zamir Doron Department of Internal Medicine D, Barzilai University Medical Center, Ashkelon Department of Psychiatry, Barzilai University Medical Center, Ashkelon Faculty of Health Studies, Ben Gurion University of the Negev, Beer Sheva, Israel Hadassah Medical Center, Jerusalem Background Fever of Unknown Origin (FUO) is a well-known medical phenomenon, Hypothesis The availability of newer imaging in the last decades, along with reported decrease in infectious diseases might had influenced dramatically the FUO prevalence. Objectives 1.To examine whether there is a decrease in the prevalence of FUO cases. 2. To examine if there is a change in the common etiologies. 3. To examine which laboratory examinations and which imagines are the most cost benefit for diagnosis. 4.Perform an investigation afterwards and find the outcome of both the undiagnosed and diagnosed patients Results 3619 patients were found to have fever for more than a week during hospitalization in 2004-16. 141 of them were found to fit into Petersdorf criteria of “FUO”. Pathogens (39%), mostly bacterial (29%) were the most common cause for FUO, although less common than in our previous study (55%). Weakness and weight loss (80%) were the most common complaints of the patients, except fever. Anemia (80%), elevated CRP (95%) and elevated ESR (97%) were the most common pathologic blood tests followed by liver function disturbances (53%). Abdominal CT, blood cultures and serology were found to be the most valuable diagnostic tests. Leukocytes scan did not contribute much to the diagnosis of FUO. Interviewing the patients three months to 12 years after having FUO, revealed that in most cases a final diagnosis was achieved in the next admission (20% out of 70% of the patients). Only 2% of patients died during the feverish episode, however 34% died within three months to 12 years. Conclusion Infections are still the most common cause for FUO, in our hospital. Most undiagnosed FUO cases, will either resolve within days of release from hospital or will be diagnosed in the same hospital or in another hospital in the upcoming admission.